A complete schedule and scoreboard for football’s top-10 teams during week four of the 2021 season is below.
CLASS 5A
| 1 | Valor Christian | 4-0 |
| Friday: W 42-7 at Mullen | ||
| 2 | Cherry Creek | 3-1 |
| Friday: W 52-21 at Arvada West | ||
| 3 | Columbine | 4-0 |
| Friday: W 49-21 vs. Highlands Ranch | ||
| 4 | Ralston Valley | 4-0 |
| Friday: W 24-13 at No. 5 Grandview | ||
| 5 | Grandview | 3-1 |
| Friday: L 13-24 vs. No. 4 Ralston Valley | ||
| 6 | Regis Jesuit | 3-1 |
| Friday: W 42-7 at Smoky Hill | ||
| 7 | ThunderRidge | 3-1 |
| Friday: L 14-38 at Arapahoe | ||
| 8 | Castle View | 3-1 |
| Friday: L 0-16 at Douglas County | ||
| 9 | Legend | 3-1 |
| Friday: W 34-7 vs. Mountain Vista | ||
| 10 | Cherokee Trail | 3-1 |
| Saturday: W 35-8 vs. Overland | ||
CLASS 4A
| 1 | Palmer Ridge | 4-0 |
| Friday: W 41-14 at Pueblo West | ||
| 2 | Dakota Ridge | 4-0 |
| Friday: W 42-2 vs. Rampart | ||
| 3 | Pine Creek | 4-0 |
| Thursday: W 45-7 vs. No. 8 Discovery Canyon (3A) | ||
| 4 | Montrose | 4-0 |
| Thursday: W 35-7 at Palisade | ||
| 5 | Chatfield | 4-0 |
| Saturday: W 28-7 at No. 10 Fruita Monument | ||
| 6 | Erie | 4-0 |
| Friday: W 50-6 vs. Longmont | ||
| 7 | Loveland | 3-1 |
| Friday: W 14-7 vs. Windsor | ||
| 8 | Golden | 4-0 |
| Friday: W 46-8 at Liberty | ||
| 9 | Fountain-Fort Carson | 3-1 |
| Friday: W 42-9 vs. Doherty | ||
| 10 | Fruita Monument | 2-2 |
| Saturday: L 7-28 vs. No. 5 Chatfield | ||
CLASS 3A
| 1 | Roosevelt | 3-0 |
| Thursday: W 63-0 vs. Harrison | ||
| 2 | Mead | 3-0 |
| Friday: W 42-0 vs. Northridge | ||
| 3 | Lutheran | 4-0 |
| Friday: W 60-0 vs. Pueblo Central | ||
| 4 | Durango | 2-2 |
| Friday: L 17-38 at Farmington (NM) | ||
| 5 | Fort Morgan | 3-0 |
| Friday: W 42-6 at Conifer | ||
| 6 | Frederick | 2-0 |
| Bye Week | ||
| 7 | Glenwood Springs | 3-1 |
| Friday: L 14-34 vs. No. 4 Basalt (2A) | ||
| 8 | Discovery Canyon | 2-2 |
| Thursday: L 7-45 at No. 3 Pine Creek (4A) | ||
| 9 | Evergreen | 4-0 |
| Saturday: W 50-6 at Gateway | ||
| 10 | Holy Family | 2-1 |
| Friday: W 28-6 vs. Green Mountain | ||
CLASS 2A
| 1 | Eaton | 3-0 |
| Saturday: W 32-0 at No. 7 Platte Valley | ||
| 2 | Resurrection Christian | 2-0 |
| Bye Week | ||
| 3 | The Classical Academy | 4-0 |
| Friday: W 42-12 vs. Elizabeth | ||
| 4 | Basalt | 4-0 |
| Friday: W 34-14 at No. 7 Glenwood Springs (3A) | ||
| 5 | Severance | 4-0 |
| Friday: W 20-7 vs. Brush | ||
| 6 | Delta | 3-1 |
| Friday: W 49-8 at Montezuma-Cortez | ||
| 7 | Platte Valley | 1-2 |
| Saturday: L 0-32 vs. No. 1 Eaton | ||
| 8 | University | 3-1 |
| Friday: L 30-38 vs. Eagle Valley | ||
| 9 | Moffat County | 3-0 |
| Bye Week | ||
| 10 | Rifle | 2-2 |
| Friday: W 42-10 vs. Faith Christian | ||
CLASS 1A
| 1 | Limon | 3-0 |
| Friday: W 46-0 at Bennett | ||
| 2 | Centauri | 4-0 |
| Friday: W 48-3 at No. 6 Strasburg | ||
| 3 | Florence | 4-0 |
| Saturday: W 36-15 vs. No. 4 Holyoke | ||
| 4 | Holyoke | 2-1 |
| Saturday: L 15-36 at No. 3 Florence | ||
| 5 | Buena Vista | 4-0 |
| Friday: W 21-8 vs. Peyton | ||
| 6 | Strasburg | 1-3 |
| Friday: L 3-48 vs. No. 2 Centauri | ||
| 7 | Wray | 3-1 |
| Saturday: W 34-0 at Burlington | ||
| 8 | North Fork | 3-0 |
| Friday: W 55-0 vs. Olathe | ||
| 9 | Wiggins | 3-0 |
| Bye Week | ||
| 10 | Highland | 2-2 |
| Friday: L 21-28 vs. Yuma | ||
8-MAN
| 1 | Sanford | 4-0 |
| Friday: W 62-0 vs. Sargent | ||
| 2 | Sedgwick County | 2-1 |
| Friday: W 18-12 vs. No. 9 Merino | ||
| 3 | Mancos | 3-0 |
| Bye Week | ||
| 4 | Haxtun | 4-0 |
| Saturday: W 50-0 vs. Caliche | ||
| 5 | Akron | 3-1 |
| Saturday: L 18-58 at No. 6 Dayspring Christian | ||
| 6 | Dayspring Christian | 3-1 |
| Saturday: W 58-18 vs. No. 5 Akron | ||
| 7 | Dove Creek | 3-1 |
| Saturday: L 14-24 at Gunnison | ||
| 8 | Simla | 2-2 |
| Saturday: L 14-16 vs. Pikes Peak Christian | ||
| 9 | Merino | 1-2 |
| Friday: L 12-18 at No. 2 Sedgwick County | ||
| 10 | Calhan | 3-0 |
| Friday: W 22-14 vs. Rangely | ||
6-MAN
| 1 | Granada | 2-1 |
| Saturday: L 20-77 at No. 2 Cheyene Wells | ||
| 2 | Cheyenne Wells | 4-0 |
| Saturday: W 77-20 vs. No. 1 Granada | ||
| 3 | Fleming | 3-1 |
| Friday: W 70-0 at Pawnee | ||
| 4 | Stratton | 2-1 |
| Bye Week | ||
| 5 | Briggsdale | 4-0 |
| Friday: W 30-28 vs. Otis | ||
| 6 | Idalia | 2-1 |
| Bye Week | ||
| 7 | Branson/Kim | 4-0 |
| Friday: W 72-20 at Cotopaxi | ||
| 8 | Prairie | 3-1 |
| Saturday: W 54-18 at Peetz | ||
| 9 | Sierra Grande | 4-0 |
| Saturday: W 33-0 at Mountain Valley | ||
| 10 | Genoa-Hugo | 3-0 |
| Bye Week | ||