A complete schedule and scoreboard for football’s top-10 teams during Week 2 of the 2022 season is below.
CLASS 5A
| 1 | Cherry Creek | 1-1 |
| Saturday: L 9-13 at St. Edward (OH) | ||
| 2 | Regis Jesuit | 1-1 |
| Saturday: L 28-34 at Oaks Christian (CA) | ||
| 3 | Grandview | 2-0 |
| Thursday: W 49-17 at Fossil Ridge | ||
| 4 | Columbine | 2-0 |
| Friday: W 35-7 at No. 7 Dakota Ridge (4A) | ||
| 5 | Valor Christian | 1-1 |
| Friday: W 24-7 vs. No. 7 Pine Creek | ||
| 6 | Ralston Valley | 1-1 |
| Friday: W 41-6 at Colonial (FL) | ||
| 7 | Pine Creek | 1-1 |
| Friday: L 7-24 at No. 5 Valor Christian | ||
| 8 | Legend | 2-0 |
| Thursday: W 42-0 vs. Pomona | ||
| 9 | ThunderRidge | 2-0 |
| Friday: W 56-0 at Douglas County | ||
| 10 | Arapahoe | 2-0 |
| Friday: W 24-14 at Heritage | ||
CLASS 4A
| 1 | Palmer Ridge | 2-0 |
| Friday: W 28-7 vs. Mesa Ridge | ||
| 2 | Ponderosa | 2-0 |
| Friday: W 44-6 at Chaparral | ||
| 3 | Pueblo West | 3-0 |
| Friday: W 41-7 at Pueblo County | ||
| 4 | Erie | 1-1 |
| Friday: W 54-34 at Mullen | ||
| 5 | Montrose | 0-2 |
| Thursday: L 14-30 at No. 10 Fruita Monument | ||
| 6 | Broomfield | 2-0 |
| Friday: W 65-7 vs. No. 4 Holy Family (3A) | ||
| 7 | Dakota Ridge | 0-2 |
| Friday: L 7-35 vs. No. 4 Columbine (5A) | ||
| 8 | Vista Ridge | 1-1 |
| Friday: W 43-28 vs. Far Northeast | ||
| 9 | Loveland | 1-1 |
| Friday: W 55-8 at Mountain View | ||
| 10 | Fruita Monument | 2-0 |
| Thursday: W 30-14 vs. No. 5 Montrose | ||
CLASS 3A
| 1 | Roosevelt | 2-0 |
| Saturday: W 41-0 at Kennedy | ||
| 2 | Mead | 1-0 |
| Monday: vs. No. 5 Lutheran | ||
| 3 | Durango | 1-1 |
| Friday: L 13-14 at Piedra Vista (NM) | ||
| 4 | Holy Family | 1-1 |
| Friday: L 7-65 at No. 6 Broomfield (4A) | ||
| 5 | Lutheran | 0-1 |
| Monday: at No. 2 Mead | ||
| 6 | Resurrection Christian | 2-0 |
| Friday: W 36-0 vs. Orangewood Christian (FL) | ||
| 7 | Northridge | 1-0 |
| Saturday: W 26-21 vs. Evergreen | ||
| 8 | Frederick | 1-1 |
| Friday: W 20-19 at Monarch | ||
| 9 | Green Mountain | 2-0 |
| Friday: W 42-0 vs. Severance | ||
| 10 | Fort Morgan | 0-2 |
| Friday: L 14-26 at No. 9 Brush (2A) | ||
CLASS 2A
| 1 | The Classical Academy | 2-0 |
| Friday: W 44-0 vs. Harrison | ||
| 2 | Delta | 2-0 |
| W at Eagle Valley (Forfeit) | ||
| 3 | Eaton | 1-1 |
| Thursday: W 41-6 at No. 7 University | ||
| 4 | Elizabeth | 2-0 |
| Friday: W 15-13 at Burlington | ||
| 5 | Platte Valley | 2-0 |
| Thursday: W 28-14 at Weld Central | ||
| 6 | Basalt | 2-0 |
| Thursday: W 43-8 vs. Battle Mountain | ||
| 7 | University | 0-2 |
| Thursday: L 6-41 vs. No. 3 Eaton | ||
| 8 | La Junta | 2-0 |
| Friday: W 32-6 at Pagosa Springs | ||
| 9 | Brush | 1-1 |
| Friday: W 26-14 vs. No. 10 Fort Morgan (3A) | ||
| 10 | Florence | 1-1 |
| Friday: W 29-7 vs. No. 2 Centauri (1A) | ||
CLASS 1A
| 1 | Limon | 2-0 |
| Friday: W 42-14 vs. No. 7 Meeker | ||
| 2 | Centauri | 1-1 |
| Friday: L 7-29 at No. 10 Florence (2A) | ||
| 3 | Wray | 2-0 |
| Friday: W 36-16 vs. Goodland (KS) | ||
| 4 | Wiggins | 1-1 |
| Friday: L 28-29 at No. 6 Strasburg | ||
| 5 | Buena Vista | 1-0 |
| Bye Week | ||
| 6 | Strasburg | 2-0 |
| Friday: W 29-28 vs. No. 4 Wiggins | ||
| 7 | Meeker | 1-1 |
| Friday: L 14-42 at No. 1 Limon | ||
| 8 | Yuma | 2-0 |
| Friday: W 28-14 at Burns (WY) | ||
| 9 | North Fork | 1-0 |
| Bye Week | ||
| 10 | Gunnison | 1-1 |
| Friday: L 7-21 vs. Alamosa | ||
8-MAN
| 1 | Haxtun | 1-0 |
| Friday: W 50-32 at Holyoke | ||
| 2 | Akron | 2-0 |
| Friday: W 40-0 vs. St. Mary’s | ||
| 3 | Mancos | 2-0 |
| Friday: W 52-13 vs. Monticello (UT) | ||
| 4 | Dove Creek | 2-0 |
| Friday: W 60-2 vs. Rangely | ||
| 5 | Merino | 2-0 |
| Friday: W 40-14 vs. McClave | ||
| 6 | Sanford | 2-0 |
| Friday: W 32-14 at No. 9 Swink | ||
| 7 | Holly | 1-0 |
| Bye Week | ||
| 8 | Simla | 2-0 |
| Friday: W 35-0 vs. Fowler | ||
| 9 | Swink | 1-1 |
| Friday: L 14-32 vs. No. 6 Sanford | ||
| 10 | Dayspring Christian Academy | 0-1 |
| Bye Week | ||
6-MAN
| 1 | Stratton | 2-0 |
| Friday: W 70-28 at No. 3 Granada | ||
| 2 | Fleming | 2-0 |
| Friday: W 44-6 vs. Idalia | ||
| 3 | Granada | 1-1 |
| Friday: L 28-70 vs. No. 1 Stratton | ||
| 4 | Cheraw | 1-1 |
| Friday: L 20-21 vs. Branson/Kim | ||
| 5 | Cheyenne Wells | 0-2 |
| Friday: L 27-45 vs. Cheylin (KS) | ||
| 6 | Sierra Grande | 1-1 |
| Friday: L 12-52 at Eads | ||
| 7 | Genoa-Hugo | 2-0 |
| Friday: W 64-25 at Kit Carson | ||
| 8 | Arickaree | 2-0 |
| Friday: W 37-14 at North Park | ||
| 9 | Briggsdale | 1-1 |
| Friday: L 7-47 vs. Otis | ||
| 10 | Prairie | 1-1 |
| Thursday: W 66-20 vs. Peetz | ||