A complete schedule and scoreboard for football’s top-10 teams during Week 4 of the 2022 season is below.
CLASS 5A
| 1 | Cherry Creek | 3-1 |
| Friday: W 62-21 vs. Arvada West | ||
| 2 | Regis Jesuit | 2-2 |
| Thursday: L 28-29 vs. No. 4 Ralston Valley | ||
| 3 | Columbine | 4-0 |
| Friday: W 28-6 vs. Arapahoe | ||
| 4 | Ralston Valley | 3-1 |
| Thursday: W 29-28 at No. 2 Regis Jesuit | ||
| 5 | Valor Christian | 2-2 |
| Friday: L 7-50 vs. Liberty (AZ) | ||
| 6 | Grandview | 3-1 |
| Thursday: W 38-37 at No. 4 Fruita Monument (4A) | ||
| 7 | Legend | 3-1 |
| Friday: L 14-21 at No. 1 Ponderosa (4A) | ||
| 8 | ThunderRidge | 4-0 |
| Thursday: W 28-13 vs. Chatfield | ||
| 9 | Pine Creek | 3-1 |
| Friday: W 66-14 at Denver East | ||
| 10 | Mountain Vista | 3-1 |
| Thursday: L 28-41 at Legacy | ||
CLASS 4A
| 1 | Ponderosa | 4-0 |
| Friday: W 21-14 vs. No. 7 Legend (5A) | ||
| 2 | Palmer Ridge | 4-0 |
| Friday: W 44-16 vs. Smoky Hill | ||
| 3 | Broomfield | 4-0 |
| Friday: W 35-14 vs. No. 10 Erie | ||
| 4 | Fruita Monument | 3-1 |
| Thursday: L 37-38 vs. No. 6 Grandview (5A) | ||
| 5 | Loveland | 3-1 |
| Friday: W 53-7 vs. Thompson Valley | ||
| 6 | Denver South | 3-1 |
| Friday: L 42-43 at Golden | ||
| 7 | Pueblo West | 3-1 |
| Bye Week | ||
| 8 | Montrose | 2-2 |
| Friday: W 40-14 vs. Palisade | ||
| 9 | Dakota Ridge | 2-2 |
| Friday: W 41-0 at Rampart | ||
| 10 | Erie | 1-3 |
| Friday: L 14-35 at No. 3 Broomfield | ||
CLASS 3A
| 1 | Roosevelt | 4-0 |
| Friday: W 25-22 at Highlands Ranch | ||
| 2 | Lutheran | 3-1 |
| Thursday: W 56-27 at No. 7 Pueblo East | ||
| 3 | Durango | 3-1 |
| Friday: W 49-14 at Grand Junction Central | ||
| 4 | Green Mountain | 4-0 |
| Friday: W 48-0 at Pueblo South | ||
| 5 | Northridge | 4-0 |
| Friday: W 49-0 at Greeley West | ||
| 6 | Resurrection Christian | 3-0 |
| Bye Week | ||
| 7 | Pueblo East | 3-1 |
| Thursday: L 27-56 vs. No. 2 Lutheran | ||
| 8 | Severance | 2-2 |
| Friday: L 0-35 vs. No. 3 Eaton (2A) | ||
| 9 | Holy Family | 2-1 |
| Friday: W 45-12 vs. Mountain View | ||
| 10 | Mead | 1-2 |
| Bye Week | ||
CLASS 2A
| 1 | The Classical Academy | 3-0 |
| Bye Week | ||
| 2 | Delta | 4-0 |
| Friday: W 20-0 vs. Rifle | ||
| 3 | Eaton | 3-1 |
| Friday: W 35-0 at No. 8 Severance (3A) | ||
| 4 | Basalt | 4-0 |
| Friday: W 28-12 vs. Glenwood Springs | ||
| 5 | The Academy | 3-0 |
| Saturday: W 54-6 vs. D’Evelyn | ||
| 6 | Brush | 1-2 |
| Friday: L 7-10 at No. 7 Yuma (1A) | ||
| 7 | Florence | 2-1 |
| Bye Week | ||
| 8 | Elizabeth | 3-1 |
| Saturday: W 14-7 at University | ||
| 9 | La Junta | 3-1 |
| Friday: W 48-6 vs. Manual | ||
| 10 | Platte Valley | 2-2 |
| Saturday: L 13-44 vs. No. 5 Wiggins (1A) | ||
CLASS 1A
| 1 | Limon | 3-0 |
| Bye Week | ||
| 2 | Buena Vista | 2-1 |
| Saturday: L 20-21 vs. Gunnison | ||
| 3 | Wray | 3-1 |
| Friday: W 49-0 at Ellicott | ||
| 4 | Strasburg | 2-1 |
| Bye Week | ||
| 5 | Wiggins | 3-1 |
| Saturday: W 44-13 at No. 10 Platte Valley (2A) | ||
| 6 | Monte Vista | 3-0 |
| Bye Week | ||
| 7 | Yuma | 4-0 |
| Friday: W 10-7 vs. No. 6 Brush (2A) | ||
| 8 | Centauri | 1-2 |
| Bye Week | ||
| 9 | Meeker | 2-1 |
| Bye Week | ||
| 10 | North Fork | 1-2 |
| Friday: L 20-49 vs. Montezuma-Cortez | ||
8-MAN
| 1 | Haxtun | 3-0 |
| Saturday: W 50-6 vs. No. 2 Mancos | ||
| 2 | Mancos | 3-1 |
| Saturday: L 6-50 at No. 1 Haxtun | ||
| 3 | Akron | 3-1 |
| Friday: L 14-27 vs. Holly | ||
| 4 | Dove Creek | 4-0 |
| Friday: W 48-26 at Hayden | ||
| 5 | Simla | 4-0 |
| Friday: W 42-23 vs. Sedgwick County | ||
| 6 | Crowley County | 4-0 |
| Friday: W 40-0 at Las Animas | ||
| 7 | Sanford | 3-1 |
| Friday: W 56-22 vs. Fowler | ||
| 8 | West Grand | 4-0 |
| Friday: W 46-0 at Elbert | ||
| 9 | Merino | 2-2 |
| Friday: L 16-36 vs. No. 10 Lyons | ||
| 10 | Lyons | 4-0 |
| Friday: W 36-16 at No. 9 Merino | ||
6-MAN
| 1 | Stratton | 4-0 |
| Saturday: W 76-34 vs. No. 3 Genoa-Hugo | ||
| 2 | Fleming | 3-0 |
| Bye Week | ||
| 3 | Genoa-Hugo | 3-1 |
| Saturday: L 34-76 at No. 1 Stratton | ||
| 4 | Arickaree | 4-0 |
| Friday: W 59-20 vs. Briggsdale | ||
| 5 | Otis | 4-0 |
| Thursday: W 46-26 at Idalia | ||
| 6 | Granada | 2-2 |
| Friday: W 102-74 at Walsh | ||
| 7 | Cheyenne Wells | 2-2 |
| Friday: W 36-14 vs. Cheraw | ||
| 8 | Branson/Kim | 3-1 |
| Saturday: W 74-0 vs. Sangre de Cristo | ||
| 9 | Eads | 3-1 |
| Friday: W 68-32 at Kit Carson | ||
| 10 | Deer Trail | 4-0 |
| Friday: W 70-0 vs. Manzanola | ||