A complete schedule and scoreboard for football’s top-10 teams during Week 6 of the 2022 season is below.
CLASS 5A
| 1 | Cherry Creek | 5-1 |
| Thursday: W 34-7 at Cherokee Trail | ||
| 2 | Columbine | 6-0 |
| Thursday: W 50-21 vs. Pomona | ||
| 3 | Valor Christian | 4-2 |
| Thursday: W 45-17 vs. Castle View | ||
| 4 | Grandview | 4-1 |
| Saturday: at Eaglecrest | ||
| 5 | Ralston Valley | 4-2 |
| Friday: W 41-6 vs. Lakewood | ||
| 6 | Regis Jesuit | 3-3 |
| Friday: W 42-7 vs. Douglas County | ||
| 7 | ThunderRidge | 6-0 |
| Friday: W 34-31 at Mountain Vista | ||
| 8 | Pine Creek | 5-1 |
| Friday: W 14-0 at Fountain-Fort Carson | ||
| 9 | Rock Canyon | 6-0 |
| Friday: W 31-7 vs. Highlands Ranch | ||
| 10 | Legacy | 4-2 |
| Thursday: W 35-14 at Rangeview | ||
CLASS 4A
| 1 | Palmer Ridge | 6-0 |
| Friday: W 49-0 vs. Rampart | ||
| 2 | Broomfield | 6-0 |
| Friday: W 55-24 at No. 10 Dakota Ridge | ||
| 3 | Ponderosa | 4-2 |
| Thursday: L 17-32 vs. No. 8 Denver South | ||
| 4 | Fruita Monument | 4-2 |
| Friday: L 13-20 vs. Heritage | ||
| 5 | Loveland | 5-1 |
| Friday: W 35-14 vs. Erie | ||
| 6 | Montrose | 4-2 |
| Thursday: W 51-20 vs. Grand Junction Central | ||
| 7 | Pueblo West | 4-2 |
| Friday: L 14-21 at Mesa Ridge | ||
| 8 | Denver South | 5-1 |
| Thursday: W 32-17 at No. 3 Ponderosa | ||
| 9 | Vista Ridge | 4-2 |
| Friday: W 46-8 at Northfield | ||
| 10 | Dakota Ridge | 2-4 |
| Friday: L 24-55 vs. No. 2 Broomfield | ||
CLASS 3A
| 1 | Roosevelt | 5-0 |
| Bye Week | ||
| 2 | Durango | 4-1 |
| Bye Week | ||
| 3 | Green Mountain | 5-0 |
| Friday: W 43-7 vs. Mead | ||
| 4 | Northridge | 5-0 |
| Bye Week | ||
| 5 | Lutheran | 3-2 |
| Bye Week | ||
| 6 | Resurrection Christian | 5-0 |
| Friday: W 56-0 vs. Sand Creek | ||
| 7 | Evergreen | 4-1 |
| Bye Week | ||
| 8 | Summit | 5-0 |
| Friday: W 62-6 vs. Lincoln | ||
| 9 | Pueblo East | 4-1 |
| Bye Week | ||
| 10 | Holy Family | 3-2 |
| Friday: W 28-7 vs. Conifer | ||
CLASS 2A
| 1 | The Classical Academy | 4-0 |
| Friday: W 56-0 vs. Alameda | ||
| 2 | Delta | 5-0 |
| Saturday: vs. Pagosa Springs | ||
| 3 | Eaton | 4-1 |
| Friday: W 41-7 vs. Steamboat Springs | ||
| 4 | Basalt | 5-0 |
| Friday: W 42-6 vs. Grand Valley | ||
| 5 | Florence | 4-1 |
| Friday: W 36-0 vs. Lamar | ||
| 6 | The Academy | 4-1 |
| Friday: W 48-14 vs. Faith Christian | ||
| 7 | Elizabeth | 4-1 |
| Friday: W 45-20 vs. Englewood | ||
| 8 | La Junta | 3-2 |
| Friday: L 20-28 at Alamosa | ||
| 9 | Moffat County | 4-1 |
| Friday: W 29-26 vs. Rifle | ||
| 10 | Montezuma-Cortez | 5-1 |
| Friday: W 19-0 vs. Salida | ||
CLASS 1A
| 1 | Limon | 4-0 |
| Saturday: at Burlington | ||
| 2 | Wray | 4-1 |
| Friday: W 53-12 vs. Holyoke | ||
| 3 | Strasburg | 4-1 |
| Thursday: W 63-6 at Clear Creek | ||
| 4 | Wiggins | 3-2 |
| Friday: L 20-23 at No. 5 Yuma | ||
| 5 | Yuma | 5-0 |
| Friday: W 23-20 vs. No. 4 Wiggins | ||
| 6 | Monte Vista | 4-0 |
| Monday: at Del Norte | ||
| 7 | Meeker | 4-1 |
| Friday: W 40-0 at Cedaredge | ||
| 8 | Buena Vista | 3-2 |
| Friday: W 42-14 vs. North Fork | ||
| 9 | Centauri | 3-2 |
| Friday: W 54-0 vs. Center | ||
| 10 | Gunnison | 4-2 |
| Friday: W 38-0 vs. Roaring Fork | ||
8-MAN
| 1 | Haxtun | 5-0 |
| Friday: W 48-14 vs. No. 8 Akron | ||
| 2 | Dove Creek | 5-0 |
| Friday: vs. No. 10 Sanford | ||
| 3 | Simla | 5-0 |
| Friday: W 54-20 vs. Calhan | ||
| 4 | Mancos | 5-1 |
| Friday: W 60-6 vs. Sargent | ||
| 5 | West Grand | 5-0 |
| Friday: W 62-0 vs. Soroco | ||
| 6 | Crowley County | 5-0 |
| Friday: W 56-20 vs. Fowler | ||
| 7 | Lyons | 5-0 |
| Thursday: W 56-14 vs. Byers | ||
| 8 | Akron | 3-2 |
| Friday: L 14-48 at No. 1 Haxtun | ||
| 9 | Holly | 4-1 |
| Friday: W 57-6 vs. Las Animas | ||
| 10 | Sanford | 4-1 |
| Friday: at No. 2 Dove Creek | ||
6-MAN
| 1 | Stratton | 6-0 |
| Friday: W 70-6 at Idalia | ||
| 2 | Fleming | 3-1 |
| Saturday: at Peetz | ||
| 3 | Otis | 6-0 |
| Friday: W 37-35 vs. No. 4 Genoa-Hugo | ||
| 4 | Genoa-Hugo | 4-2 |
| Friday: L 35-37 at No. 3 Otis | ||
| 5 | Granada | 4-2 |
| Friday: W 54-22 vs. No. 10 Cheraw | ||
| 6 | Arickaree | 4-1 |
| Saturday: at Hi-Plains | ||
| 7 | Cheyenne Wells | 2-3 |
| Saturday: vs. Kit Carson | ||
| 8 | Branson/Kim | 4-1 |
| Saturday: at Primero | ||
| 9 | Deer Trail | 6-0 |
| Friday: W 37-7 vs. Weskan (KS) | ||
| 10 | Cheraw | 2-4 |
| Friday: L 22-54 at No. 5 Granada | ||