A complete schedule and scoreboard for football’s top-10 teams during week six of the 2021 season is below.
CLASS 5A
| 1 | Valor Christian | 6-0 |
| Friday: W 49-6 vs. Mountain Vista | ||
| 2 | Cherry Creek | 5-1 |
| Friday: W 41-10 at No. 8 Cherokee Trail | ||
| 3 | Columbine | 4-2 |
| Friday: L 21-24 at Arvada West | ||
| 4 | Ralston Valley | 6-0 |
| Friday: W 40-14 at Mullen | ||
| 5 | Grandview | 5-1 |
| Thursday: W 23-6 vs. Smoky Hill | ||
| 6 | Regis Jesuit | 4-2 |
| Friday: W 56-14 vs. Chaparral | ||
| 7 | Legend | 5-1 |
| Friday: W 26-23 vs. No. 2 Pine Creek (4A) | ||
| 8 | Cherokee Trail | 4-2 |
| Friday: L 10-41 vs. No. 2 Cherry Creek | ||
| 9 | Arapahoe | 5-1 |
| Thursday: W 35-14 vs. Eaglecrest | ||
| 10 | Douglas County | 6-0 |
| Saturday: W 26-8 vs. Doherty | ||
CLASS 4A
| 1 | Palmer Ridge | 5-1 |
| Friday: L 21-28 vs. No. 4 Montrose | ||
| 2 | Pine Creek | 5-1 |
| Friday: L 23-26 at No. 7 Legend (5A) | ||
| 3 | Dakota Ridge | 6-0 |
| Friday: W 52-13 vs. Bear Creek | ||
| 4 | Montrose | 6-0 |
| Friday: W 28-21 at No. 1 Palmer Ridge | ||
| 5 | Erie | 6-0 |
| Friday: W 51-21 vs. Silver Creek | ||
| 6 | Loveland | 5-1 |
| Thursday: W 42-0 vs. Monarch | ||
| 7 | Chatfield | 5-1 |
| Thursday: W 56-14 vs. Wheat Ridge | ||
| 8 | Ponderosa | 5-1 |
| Thursday: W 60-7 at Air Academy | ||
| 9 | Golden | 6-0 |
| Friday: W 28-6 vs. Standley Lake | ||
| 10 | Fountain-Fort Carson | 5-1 |
| Friday: W 7-0 at Mesa Ridge | ||
CLASS 3A
| 1 | Roosevelt | 5-0 |
| Friday: W 42-0 at Glenwood Springs | ||
| 2 | Lutheran | 5-0 |
| Off Week | ||
| 3 | Mead | 4-0 |
| Off Week | ||
| 4 | Fort Morgan | 4-0 |
| Off Week | ||
| 5 | Frederick | 4-0 |
| Friday: W 42-16 vs. No. 8 Eagle Valley | ||
| 6 | Durango | 3-2 |
| Off Week | ||
| 7 | Evergreen | 5-0 |
| Friday: W 41-23 vs. George Washington | ||
| 8 | Eagle Valley | 3-1 |
| Friday: L 16-42 at No. 5 Frederick | ||
| 9 | Holy Family | 2-2 |
| Off Week | ||
| 10 | Palisade | 3-2 |
| Off Week | ||
CLASS 2A
| 1 | Eaton | 5-0 |
| Saturday: W 42-6 at No. 10 The Academy | ||
| 2 | Resurrection Christian | 4-0 |
| Friday: W 45-0 vs. Berthoud | ||
| 3 | The Classical Academy | 4-0 |
| Friday: W 45-7 vs. La Junta | ||
| 4 | Severance | 5-0 |
| Thursday: W 34-13 vs. No. 8 University | ||
| 5 | Basalt | 4-1 |
| Friday: L 6-19 vs. No. 6 Moffat County | ||
| 6 | Moffat County | 5-0 |
| Friday: W 19-6 at No. 5 Basalt | ||
| 7 | Delta | 4-1 |
| Friday: W 63-0 at Coal Ridge | ||
| 8 | University | 3-2 |
| Thursday: L 13-34 at No. 4 Severance | ||
| 9 | Rifle | 2-3 |
| Friday: L 19-34 at Aspen | ||
| 10 | The Academy | 4-1 |
| Saturday: L 6-42 vs. No 1 Eaton | ||
CLASS 1A
| 1 | Limon | 5-0 |
| Friday: W 34-10 at No. 9 Yuma | ||
| 2 | Centauri | 5-0 |
| Friday: W 60-6 vs. Center | ||
| 3 | Florence | 6-0 |
| Friday: W 52-0 at Rye | ||
| 4 | Buena Vista | 6-0 |
| Friday: W 28-21 at No. 5 North Fork | ||
| 5 | North Fork | 4-1 |
| Friday: L 21-28 vs. No. 4 Buena Vista | ||
| 6 | Wray | 4-1 |
| Friday: W 20-7 vs. No. 7 Wiggins | ||
| 7 | Wiggins | 4-1 |
| Friday: L 7-20 at No. 6 Wray | ||
| 8 | Holyoke | 4-1 |
| Friday: W 34-12 at Burlington | ||
| 9 | Yuma | 3-2 |
| Friday: L 10-34 vs. No. 1 Limon | ||
| 10 | Strasburg | 3-3 |
| Saturday: W 19-7 vs. Highland | ||
8-MAN
| 1 | Mancos | 5-0 |
| Friday: W 22-14 at No. 6 Dove Creek | ||
| 2 | Sedgwick County | 3-1 |
| Off Week | ||
| 3 | Haxtun | 6-0 |
| Friday: W 64-20 vs. No. 8 Merino | ||
| 4 | Sanford | 4-1 |
| Off Week | ||
| 5 | Vail Christian | 5-0 |
| Saturday: W 40-14 vs. Plateau Valley | ||
| 6 | Dove Creek | 3-2 |
| Friday: L 14-22 vs. No. 1 Mancos | ||
| 7 | Dayspring Christian | 4-2 |
| Friday: W 48-14 at Caliche | ||
| 8 | Merino | 2-3 |
| Friday: L 20-64 at No. 3 Haxtun | ||
| 9 | Akron | 3-2 |
| Off Week | ||
| 10 | Holly | 4-1 |
| Friday: W 41-14 at McClave | ||
6-MAN
| 1 | Cheyenne Wells | 5-0 |
| Saturday: at Walsh (Canceled) | ||
| 2 | Stratton | 4-1 |
| Friday: W 32-16 vs. No. 6 Idalia | ||
| 3 | Granada | 4-1 |
| Friday: W 51-19 vs. Flagler | ||
| 4 | Fleming | 5-1 |
| Friday: W 62-18 at Weldon Valley | ||
| 5 | Prairie | 5-1 |
| Friday: W 60-28 vs. No. 9 Briggsdale | ||
| 6 | Idalia | 3-2 |
| Friday: L 16-32 at No. 2 Stratton | ||
| 7 | Branson/Kim | 5-0 |
| Off Week | ||
| 8 | Sierra Grande | 5-0 |
| Off Week | ||
| 9 | Briggsdale | 5-1 |
| Friday: L 28-60 at No. 5 Prairie | ||
| 10 | Genoa-Hugo | 5-0 |
| Friday: W 73-25 vs. Miami-Yoder | ||