The 2021 regional tournaments for Class 5A softball.
2021 CHSAA Class 5A Softball Regionals Class 5A Region 1
2021 CHSAA Class 5A Softball Regionals Class 5A Region 2
2021 CHSAA Class 5A Softball Regionals Class 5A Region 3
2021 CHSAA Class 5A Softball Regionals Class 5A Region 4
2021 CHSAA Class 5A Softball Regionals Class 5A Region 5
2021 CHSAA Class 5A Softball Regionals Class 5A Region 6
2021 CHSAA Class 5A Softball Regionals Class 5A Region 7