A complete schedule and scoreboard for football’s top-10 teams during Week 1 of the 2022 season is below.
CLASS 5A
| 1 | Cherry Creek | 1-0 |
| Friday: W 35-21 at No. 6 Ralston Valley | ||
| 2 | Valor Christian | 0-1 |
| Friday: L 23-17 vs. No. 4 Regis Jesuit | ||
| 3 | Grandview | 1-0 |
| Friday: W 41-6 at Overland | ||
| 4 | Regis Jesuit | 1-0 |
| Friday: W 23-17 at No. 2 Valor Christian | ||
| 5 | Columbine | 1-0 |
| Friday: W 42-19 vs. Mullen | ||
| 6 | Ralston Valley | 0-1 |
| Friday: L 35-21 vs. No. 1 Cherry Creek | ||
| 7 | Pine Creek | 1-0 |
| Friday: W 43-3 at Las Vegas (NV) | ||
| 8 | Legend | 1-0 |
| Friday: W 47-43 at No. 6 Vista Ridge (4A) | ||
| 9 | Arvada West | 0-1 |
| Friday: L 34-28 at ThunderRidge | ||
| 10 | Arapahoe | 1-0 |
| Thursday: W 10-3 vs. Legacy | ||
CLASS 4A
| 1 | Erie | 0-1 |
| Friday: L 39-27 vs. No. 7 Ponderosa | ||
| 2 | Montrose | 0-1 |
| Friday: L 35-28 vs. No. 4 Palmer Ridge | ||
| 3 | Dakota Ridge | 0-1 |
| Friday: L 21-14 at No. 9 Pueblo West | ||
| 4 | Palmer Ridge | 1-0 |
| Friday: W 35-28 at No. 2 Montrose | ||
| 5 | Loveland | 0-1 |
| Thursday: L 36-35 at Fossil Ridge | ||
| 6 | Vista Ridge | 0-1 |
| Friday: L 47-43 vs. No. 8 Legend (5A) | ||
| 7 | Ponderosa | 1-0 |
| Friday: W 39-27 at No. 1 Erie | ||
| 8 | Broomfield | 1-0 |
| Friday: W 47-14 vs. Longmont | ||
| 9 | Pueblo West | 2-0 |
| Friday W 21-14 vs. No. 3 Dakota Ridge | ||
| 10 | Fruita Monument | 1-0 |
| Friday: W 14-7 at Grand Junction Central | ||
CLASS 3A
| 1 | Mead | 1-0 |
| Friday: W 35-34 vs. Windsor | ||
| 2 | Roosevelt | 1-0 |
| Friday: W 35-18 vs. No. 7 Palisade | ||
| 3 | Fort Morgan | 0-1 |
| Thursday: L 13-10 vs. Conifer | ||
| 4 | Lutheran | 0-1 |
| Friday: L 26-16 vs. Lutheran (MO) | ||
| 5 | Durango | 1-0 |
| Friday: W 56-7 vs. Farmington (NM) | ||
| 6 | Holy Family | 1-0 |
| Friday: W 27-26 at No. 8 Frederick | ||
| 7 | Palisade | 0-1 |
| Friday: L 35-18 at No. 2 Roosevelt | ||
| 8 | Frederick | 0-1 |
| Friday: L 27-26 vs. No. 6 Holy Family | ||
| 9 | Northridge | 1-0 |
| Thursday: W 52-0 at Gateway | ||
| 10 | Resurrection Christian | 1-0 |
| Friday: W 36-6 at No. 10 Moffat County (2A) | ||
CLASS 2A
| 1 | Eaton | 0-1 |
| Friday: L 19-16 at No. 3 Classical Academy | ||
| 2 | Delta | 1-0 |
| Friday: W 24-0 vs. No. 5 University | ||
| 3 | The Classical Academy | 1-0 |
| Friday: W 19-16 vs. No. 1 Eaton | ||
| 4 | Brush | 0-1 |
| Friday: L 27-7 at No. 6 Wiggins (1A) | ||
| 5 | University | 0-1 |
| Friday: L 24-0 at No. 2 Delta | ||
| 6 | Elizabeth | 1-0 |
| Friday: W 38-24 vs. D’Evelyn | ||
| 7 | Platte Valley | 1-0 |
| Saturday: W 21-20 at Kent Denver | ||
| 8 | Florence | 0-1 |
| Friday: L 20-3 at No. 1 Limon (1A) | ||
| 9 | Basalt | 1-0 |
| Friday: W 39-16 at Eagle Valley | ||
| 10 | Moffat County | 0-1 |
| Friday: L 36-6 vs. No. 10 Resurrection Christian (3A) | ||
CLASS 1A
| 1 | Limon | 1-0 |
| Friday: W 20-3 vs. No. 8 Florence (2A) | ||
| 2 | Centauri | 1-0 |
| Friday: W 33-0 vs. Pagosa Springs | ||
| 3 | Wray | 1-0 |
| Friday: W 46-0 at Highland | ||
| 4 | Buena Vista | 1-0 |
| Thursday: W 26-16 at Salida | ||
| 5 | Strasburg | 1-0 |
| Friday: W 37-6 vs. No. 9 Holyoke | ||
| 6 | Wiggins | 1-0 |
| Friday: W 27-7 vs. No. 4 Brush (2A) | ||
| 7 | Meeker | 1-0 |
| Friday: W 28-0 at No. 8 North Fork | ||
| 8 | North Fork | 0-1 |
| Friday: L 28-0 vs. No. 7 Meeker | ||
| 9 | Holyoke | 0-1 |
| Friday: L 37-6 at No. 5 Strasburg | ||
| 10 | Yuma | 1-0 |
| Thursday: W 56-14 vs. Sterling | ||
8-MAN
| 1 | Haxtun | 0-0 |
| Bye Week | ||
| 2 | Mancos | 1-0 |
| Friday: W 46-8 at Melrose (NM) | ||
| 3 | Akron | 1-0 |
| Friday: W 50-26 at Byers | ||
| 4 | Dove Creek | 1-0 |
| Friday: W 54-0 vs. Plateau Valley | ||
| 5 | Dayspring Christian Academy | 0-1 |
| Friday: L 34-20 at No. 9 Sanford | ||
| 6 | Holly | 1-0 |
| Saturday: W 44-8 at Custer County | ||
| 7 | Sedgwick County | 0-1 |
| Thursday: L 54-14 at Dundy County-Stratton (NE) | ||
| 8 | Merino | 1-0 |
| Saturday: W 44-0 at Pikes Peak Christian | ||
| 9 | Sanford | 1-0 |
| Friday: W 34-20 vs. No. 5 Dayspring Christian Academy | ||
| 10 | Simla | 1-0 |
| Friday: W 50-6 at Hoehne | ||
6-MAN
| 1 | Stratton | 1-0 |
| Friday: W 53-6 at No. 3 Cheyenne Wells | ||
| 2 | Fleming | 1-0 |
| Saturday: W 45-12 vs. North Park | ||
| 3 | Cheyenne Wells | 0-1 |
| Friday: L 53-6 vs. No. 1 Stratton | ||
| 4 | Granada | 1-0 |
| Saturday: W 68-24 at Branson/Kim | ||
| 5 | Idalia | 0-1 |
| Friday: L 13-7 vs. Briggsdale | ||
| 6 | Prairie | 0-1 |
| Saturday: L 55-36 vs. No. 7 Cheraw | ||
| 7 | Cheraw | 1-0 |
| Saturday: W 55-36 at No. 6 Prairie | ||
| 8 | Sierra Grande | 1-0 |
| Friday: W 78-6 at Manzanola | ||
| 9 | Arickaree | 1-0 |
| Thursday: W 54-0 vs. Bethune | ||
| 10 | Genoa-Hugo | 1-0 |
| Friday: W 70-50 vs. Eads | ||